How are ISAC result reports being interpreted?

On top of each page of the ISAC result report, you’ll find relevant data of each patient.

 The allergens analyzed with ISAC are classified according to particular groups. For example, one such group contains allergens from tree and grass pollen. Beneath the group name you’ll find a list of the allergens belonging to this particular group. The group name is indicated only on top of the list.

 Next to indicating the allergen source (i.e. the biological source containing a particular allergen molecule), the report contains the latin name (e.g. betula verrucosa) of each allergen as well as a common name (e.g. European White Birch). In cases where more than one allergen molecule per allergen source is included, the report indicates the allergen source only once while the specific results for the individual molecules are listed below. The exemplary report shown above contains three allergen-specific results for the European White Birch (Bet v 1, Bet v 1.0401 und Bet v 2).

 Next, the official scientific designation of each allergen and the host for recombinant protein expression (if applicable) are quoted (3). For example, EC indicates that the corresponding allergen has been produced by recombinant protein expression in E. coli. NN indicates that the allergen has been purified in its natural form from the corresponding biological source.

 The semi-quantitative ISAC results are listed in the ”ISAC Class“ column. The results are divided into four different classes, namely “Negative”, “Low”, “Moderate” and “High”. In addition, the results are also presented using an asterisk-based classification, one, two and three asterisks correlating to “Low”, “Moderate” and “High” results, respectively. “Low”, “Moderate” and “High” results contain IgE values corresponding to UniCAP classes 1-2, 3-4, and 5-6, respectively.